Nuclear shape and orientation features from H&E images predict survival in early-stage estrogen receptor-positive breast cancers

Early-stage estrogen receptor-positive (ER+) breast cancer (BCa) is the most common type of BCa in the United States. One critical question with these tumors is identifying which patients will receive added benefit from adjuvant chemotherapy. Nuclear pleomorphism (variance in nuclear shape and morphology) is an important constituent of breast grading schemes, and in ER+ cases, the grade is highly correlated with disease outcome. This study aimed to investigate whether quantitative computer-extracted image features of nuclear shape and orientation on digitized images of hematoxylin-stained and eosin-stained tissue of lymph node-negative (LN?), ER+ BCa could help stratify patients into discrete (<10 years short-term vs. >10 years long-term survival) outcome groups independent of standard clinical and pathological parameters ...


Información adicional

País:     ---

Autor(es):   

  • David Edmundo Romo
  • Cheng Lu
  • Xiangxue Wang
  • Andrew Janowczyk
  • Shridar Ganesan
  • Hannah Gilmore
  • David Rimm
  • Anant Madabhushi

Año:     2018

ISSN:    ---

Revista:    Laboratory Investigation

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